Mitomycin instructions for use
Application of Mitomycin
Stomach cancer, pancreatic cancer, esophageal cancer, liver cancer, bile duct cancer, colon and rectal cancer, breast cancer, cervical cancer, vulvar cancer, endometrial cancer, non-small cell lung cancer, mesothelioma, renal pelvis and ureter cancer, cancer bladder, prostate cancer, malignant tumors of the head and neck, chronic myelocytic leukemia.
Dosage regimen
They are set individually, depending on the indications and stage of the disease, the state of the hematopoietic system, and the antitumor therapy regimen.
Contraindications
Hypersensitivity, incl. a history of intolerance phenomena or a hypertensive reaction in response to the administration of mitomycin, severe bone marrow hypoplasia, thrombocytopenia, coagulopathy, incl. tendency to bleeding, severe chronic renal failure (with plasma creatinine concentration >1.7 mg/100 ml), acute infectious diseases of a viral, fungal or bacterial nature, incl. chicken pox, herpes zoster (risk of severe generalization of the disease), pregnancy, breastfeeding.
Restrictions on use
Suppression of bone marrow function, incl. due to treatment with cytotoxic drugs or radiation therapy, childhood.
Special instructions
It is necessary to follow safety precautions and rules when preparing and diluting mitomycin (in a sterile box using disposable surgical gloves and masks) and destroying needles, syringes, vials, ampoules and unused drug residues.
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