Dorucin / Dorucin Doxorubicin fl. 50mg/25ml instructions for use
Release form
Lyophilisate for preparing a solution for intravascular and intravesical administration.
Pharmacodynamics
Antitumor antibiotic of the anthracycline series. has antimitotic and antiproliferative effects.
Indications
Lymphoblastic leukemia, soft tissue sarcoma, osteogenic sarcoma, Ewing’s sarcoma, breast cancer, thyroid cancer, Wilms tumor, neuroblastoma, bladder cancer, stomach cancer, ovarian cancer, lymphogranulomatosis, non-Hodgkin’s lymphomas, trophoblastic tumors, refractory ovarian cancer, Kaposi’s sarcoma .
Side effect
From the hematopoietic system: thrombocytopenia, leukopenia, anemia. From the cardiovascular system: cardiomyopathy, heart failure, arrhythmias. From the digestive system: stomatitis, esophagitis, abdominal pain; nausea, vomiting, diarrhea. From the reproductive system: azoospermia, amenorrhea. Allergic reactions: urticaria, fever, anaphylactoid reactions. Other: alopecia, hyperuricemia, nephropathy. Local reactions: when injected into small-diameter veins or when injected repeatedly into the same vein — sclerosis of the vessel; with extravasation — tissue necrosis.
Contraindications
Severe leukopenia, anemia, thrombocytopenia; severe diseases of the cardiovascular system; acute hepatitis; pregnancy. Doxorubicin Dorucin is not used in patients who have received the full cumulative dose of daunorubicin, idarubicin and/or other anthracyclines and anthracenes.
Pregnancy and lactation
Doxorubicin Dorucin is contraindicated for use during pregnancy in the first trimester; its use is possible in the second and third. If necessary, use during lactation should stop breastfeeding. Women of childbearing potential should use reliable methods of contraception when using doxorubicin. Experimental studies have established the teratogenic and embryotoxic effects of doxorubicin.
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