ENTEKOR 0.5MG (ENTECAVIR)

The active ingredient of the drug «Entekor 0.5» from Natco Pharma is entecavir — a powerful antiviral agent that is suitable for patients with various stages of hepatitis B with or without liver cirrhosis. Entecavir is an international nonproprietary name for a guanosine analogue.

Characteristics

The drug form is tablets for oral administration.
The tablets are film-coated.
In addition to the active substance in the amount of 0.5 mg or 1 mg, Baraclude contains excipients.
The tablets are supplied in a plastic jar.
Quantity per package — 30.
Recommended time of administration — on an empty stomach 2 hours before or 2 hours after meals (fatty foods impair the absorption of the active substance).
The course of treatment is 96 weeks or more.
Shelf life — for 2 years at a temperature of +15 to +25 degrees.

Description

Baraclude is a carbocyclic analogue of 2′-deoxyguanosine, has high antiviral activity, is well tolerated, the risk of developing resistance to the drug is minimal. Entecavir is absorbed in the gastrointestinal tract, the maximum concentration in the blood is reached after 0.5-1.5 hours. The blood carries the substance throughout the body, it enters the tissues and begins to work. It is excreted in the urine (60-75%).

The drug works with the DNA polymerase enzyme of the virus that causes hepatitis B. After entering the body and undergoing several transformations, the substance turns into triphosphate — an active metabolite.

It affects three stages of DNA polymerase, which increases the effectiveness of treatment:

• initiation stage — the part of the DNA containing information about the polymerase is copied;
• elongation stage — the negative strand of RNA is transcribed;
• termination stage — the polymerase leads to the synthesis of the positive strand of viral RNA.

Suppression of the active process at all three stages under the influence of Entecavir tablets guarantees suspension of the virus, improvement of the patient’s condition and leads to an inactive phase of virus carriage in the vast majority of cases.

Baraclude treatment is prescribed for chronic hepatitis B even at its advanced stages with complications:

• with elevated transaminase levels;
• with high viremia;
• with liver fibrosis;
• with liver damage in the stages of decompensation and compensation;
• with hepatitis in the active phase.

Side effects

Generic analogues are well tolerated, the occurrence of side effects is unlikely.

Possible symptoms:

• Lactic acidosis, severe hepatomegaly, steatosis — more often observed in female patients, expressed in nausea, vomiting, abdominal pain, fatigue, muscle weakness, weight loss;
• when stopping therapy — exacerbation of hepatitis (the patient’s liver function should be monitored after discontinuation, as a rule, the symptom goes away without serious consequences);
• with resistance to lamivudine — an increased risk of viral resistance to entecavir.

Side effects of Entecavir in tablet form usually occur in patients with decompensated liver cirrhosis, renal failure, mixed hepatitis. Rare side effects of generics from India include dizziness, headaches, sleep disturbances, skin rash, hair loss, allergic reactions, fatigue. In order to exclude the occurrence of undesirable effects or to record their manifestation in time, it is necessary to undergo regular examination during treatment. Taking the drug is possible only after consultation with a doctor.

Contraindications include individual intolerance to the components, age under 18, pregnancy, breastfeeding (therapy is possible when stopping breastfeeding), lactase deficiency. When treating HIV patients who do not receive antiretroviral therapy – the emergence of resistant HIV strains. The use of Entecavir for the treatment of HIV-infected patients is not advisable.

Course of treatment

Baraclude is one of the inexpensive drugs that are used to treat such a serious pathology. A one-year course (52 weeks) requires 13 packages.

Recommended doses:

• with compensated liver damage – 0.5 mg per day;
• with decompensated liver damage and resistance to lamivudine – 1 mg per day (per dose);
• with renal failure – course correction on an individual basis, for example, with CC less than 50 ml/min, the intervals between doses can be from 2 to 7 days.

The cost of a course of treatment from 3 months is 9,000 rubles (the price of 1 package of 30 tablets is 3,000 rubles). The price per package is reduced if you buy several jars in bulk – a one-year course will also be inexpensive. Leave a request for a consultation, and our manager will calculate the cost of the entire course taking into account the current price.

Delivery

You can buy generics Baraclude on our website and be sure of fast and reliable delivery.