Indenza / Indenza — instructions for use
The main active component of the drug is enzalutamide. The medicine contains no additional substances.
Release form
The medicine is available in capsules. Each package contains 112 capsules.
Pharmacological properties
The substance enzalutamide acts as an androgen receptor inhibitor, affecting different stages of the disease. The drug promotes inhibition and binding of androgens to their receptors, while simultaneously provoking the translocation of receptors and further interaction with DNA cells. Thanks to this, it is possible to reduce the proliferation of prostate cancer cells, due to which apoptosis and tumor shrinkage occur. The drug helps reduce the effect of testosterone on the functioning of the adrenal glands. Thanks to the action of the drug, cancer cells lose the ability to reproduce.
Pharmacokinetics
The drug completely dissolves in the human body in just 3 hours. The active substance is concentrated in the liver, after which it is evenly distributed throughout the tumor, actively acting on cancer cells. Having completed its task, 50% of the drug is eliminated within 3-11 days.
Application
The drug is an androgen receptor inhibitor for the treatment of patients who suffer from prostate cancer, namely:
- metastatic castration-resistant prostate cancer. Used in cases where other chemotherapy has not yielded positive results;
- metastatic castration-sensitive prostate cancer. Use is recommended if other options for hormonal therapy are not effective.
Contraindications
The use of the medicine is not recommended for patients who are predisposed to an allergic reaction to any of its constituent components.
Side effects
Among the most common negative actions are:
- attacks of severe fatigue;
- painful sensations in muscles and joints;
- back and bone pain;
- diarrhea;
- frequent dizziness and weakness;
- swelling of the arms and legs;
- migraine;
- anxiety and stress.
More rarely, the color of the urine may change, becoming pink or red. A rash appears on the skin, problems with sleep and the respiratory system begin to arise, a strong feeling of weakness, pain in the lower back, high blood pressure, numbness and burning of the skin, and agitation.
Interaction with other drugs
The drug is not recommended to be taken simultaneously with the following medications:
- painkillers;
- antibiotic;
- anticancer drugs;
- anticoagulants;
- antiepileptic medicine;
- antipsychotic;
- corticosteroid;
- sleeping pills;
- thyroid hormone.
Application and dosage
The drug is taken orally once a day, subject to a dosage of 160 mg, regardless of food intake. In case of side effects, the dose is reduced to 120-80 mg.
Overdose
If an overdose occurs, seizures may occur. To get rid of symptoms, you must stop treatment immediately.
Special instructions
The drug should be taken with particular caution in patients who:
- have a history of;
- suffer from sudden changes in behavior that are associated with impaired brain function;
- suffer from symptoms such as migraines, low blood pressure and blurred vision;
- have kidney and liver diseases;
- belong to the risk group for cardiovascular diseases;
- have an allergic reaction manifested by swelling of the tongue, pharynx and lips or lactose intolerance.
Use during lactation and pregnancy
The drug is prohibited for use in pregnant women and during breastfeeding.
Effect on driving
During treatment with the drug, it is not recommended to drive a car or other equipment, which explains the high likelihood of attention problems and memory problems.
Terms of sale
The medicine is sold as prescribed by a doctor.
Storage
The medicine should be stored in a place inaccessible to children where the temperature does not exceed 25C.
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